ONLINE RESOURCES

Links to medically relevant resources you might find helpful in the treatment of GERD

WEBSITES

PubMed

  • More than 17 million citations from MEDLINE and other life science journals dating back to the 1950s
  • Links to full-text articles and other related resources

American College of Gastroenterology (ACG) Annual Scientific Meeting

  • Yearly clinical meeting for GI professionals
  • Online abstract and registration submission forms, education programs and exhibitor list

Digestive Disease Week (DDW)

  • Week-long meeting for GI physicians and researchers
  • Downloadable program, exhibitor list, online registration and e-mail updates

Pri-Med

  • National meetings for primary care professionals throughout the year
  • Local meetings by ZIP code, online registration, session topics and CME course work

SUGGESTED PROFESSIONAL JOURNALS (Subscription may be required to access content.)

Alimentary Pharmacology and Therapeutics

  • International journal emphasizing the effects of drugs on the gastrointestinal and hepatobiliary systems

American Family Physician

  • Official clinical journal of the American Academy of Family Physicians, one of the largest national medical organizations

American Journal of Gastroenterology

  • Official publication of the American College of Gastroenterology
  • Latest information on digestive health through clinical reviews, editorials and CME access

American Journal of Physiology, Gastrointestinal and Liver Physiology

  • Original articles on research involving normal and abnormal function of the gastrointestinal tract, hepatobiliary system and pancreas

Annals of Internal Medicine

  • Leading journal for studies in internal medicine, established by the American College of Physicians
  • Peer-reviewed articles, structured abstracts and twice-monthly distribution

British Medical Journal

  • Original scientific studies, educational articles and reviews focusing on worldwide health

Clinical Advisor

  • Monthly journal for NPs and PAs focusing on the latest information about diagnosing, treating, managing and preventing conditions in primary care

Current Opinion in Gastroenterology

  • Bimonthly resource focusing on 1 or 2 pertinent topics
  • Guest editors and experts assess developments from the previous year

Digestive Diseases and Sciences

  • Monthly journal focusing on basic research and clinical practice information in gastroenterology and hepatology

Digestive and Liver Disease

  • International journal with original papers, clinical observations, editorials, reviews and special articles focused on gastroenterology and hepatology

Doctor's Digest

  • Single-topic, in-depth information and expert advice to help physicians run their practices more efficiently

Gastroenterology

  • Official journal of the American Gastroenterological Association Institute
  • Current and authoritative coverage of basic and clinical gastroenterology and the latest in disease treatments

GUT

  • Official journal of the British Society of Gastroenterology
  • Leading international journal with current, authoritative, clinically oriented coverage of all areas of gastroenterology

Journal of the American Academy of Physician Assistants

  • Peer-reviewed, clinical journal with current information and research on clinical, health policy and professional issues

Journal of the American Medical Association

  • International, peer-reviewed, general medical journal offering articles, reviews, editorials and CME access

Journal of Clinical Gastroenterology

  • Collection of the world's most relevant clinical studies and reviews, case reports and technical expertise
  • Biographies, focused organ reviews, practice management, therapeutic recommendations and grand rounds

Journal of Family Practice

  • Preferred source of medical information for family physicians, family medicine researchers and other primary care clinicians

Journal of Gastroenterology

  • Official publication of the Japanese Society of Gastroenterology
  • Original papers, case reports, multicenter trials, review articles and short and rapid communications

Lancet

  • The world's leading international, independent general medical journal
  • Peer-reviewed, diverse content featuring high-quality clinical trials and review articles

New England Journal of Medicine

  • Weekly medical journal providing research findings, review articles and editorials on topics in internal medicine
 
INDICATIONS
  • In adults (≥18 years of age), ACIPHEX® 20 mg is indicated for: treatment of daytime and nighttime heartburn and other symptoms associated with GERD; short-term, up to 4 weeks, treatment in the healing and symptomatic relief of duodenal ulcers; short-term, 4 to 8 weeks, treatment in the healing and symptomatic relief of erosive GERD; and maintenance of healing and reduction in relapse rates of heartburn symptoms in erosive GERD (controlled maintenance studies do not extend beyond 12 months)
  • In adults, ACIPHEX® 20 mg bid, in combination with amoxicillin 1000 mg bid and clarithromycin 500 mg bid, for 7 days is indicated for H. pylori eradication to reduce the risk of duodenal ulcer recurrence
  • In adolescent patients 12 years of age and above, ACIPHEX® 20 mg is indicated for: short-term, up to 8 weeks, treatment of daytime and nighttime heartburn and other symptoms associated with GERD
IMPORTANT SAFETY INFORMATION
Contraindications:
  • ACIPHEX® is contraindicated in patients with known hypersensitivity to rabeprazole, substituted benzimidazoles, or to any component of the formulation
Warnings and Precautions:
  • Symptomatic response to therapy does not preclude the presence of gastric malignancy
  • As with all PPIs, patients treated concomitantly with warfarin may need to be monitored for increases in INR and prothrombin time. Increases in INR and prothrombin time may lead to abnormal bleeding and even death
  • Long-term and multiple daily dose PPI therapy may be associated with an increased risk for osteoporosis-related fractures of the hip, wrist or spine
  • Hypomagnesemia has been reported rarely with prolonged treatment with PPIs. Serious adverse events include tetany, arrhythmias, and seizures. Consider monitoring magnesium levels in patients on prolonged PPI therapy or concomitant medications such as digoxin or medications that may cause hypomagnesemia (eg, diuretics)
Adverse Events:
  • In adolescents, the related reported adverse reactions that occurred in ≥2% of patients were headache and nausea. The adverse reactions reported without regard to relationship to ACIPHEX® that occurred in ≥2% of patients were headache, diarrhea, nausea, vomiting, and abdominal pain
  • In adults, clinical trials revealed the following adverse reactions appearing in ≥2% of ACIPHEX® patients and with a frequency greater than placebo: pain, pharyngitis, flatulence, infection, and constipation
Drug Interactions:
  • ACIPHEX® inhibits gastric acid secretion and may interfere with the absorption of drugs where gastric pH is an important determinant of bioavailability (eg, ketoconazole, iron salts and digoxin)
  • ACIPHEX® may reduce the plasma levels of atazanavir
  • Rabeprazole has been shown to inhibit cyclosporine metabolism in vitro
Use of ACIPHEX® for H. pylori Eradication:
  • In H. pylori clinical trials using combination therapy with rabeprazole sodium plus amoxicillin and clarithromycin (RAC), no adverse events unique to this drug combination were observed. In the US multicenter study, the most frequently reported drug-related adverse events for patients who received RAC therapy for 7 days were diarrhea (8%) and taste perversion (6%)
  • No clinically significant laboratory abnormalities particular to the drug combinations were observed
  • Clarithromycin is contraindicated in patients taking cisapride or pimozide; or in patients with a known hypersensitivity to clarithromycin or any macrolide antibiotic. Clarithromycin may elevate digoxin serum concentrations. Serum digoxin levels should be carefully monitored while digoxin and clarithromycin are taken concomitantly. Clarithromycin should not be used in pregnant women except in circumstances where no alternative therapy is appropriate. (See WARNINGS and Drug Interactions in Prescribing Information for clarithromycin.) Amoxicillin is contraindicated in patients who are allergic to any penicillin
  • For more information on adverse events or laboratory changes with amoxicillin or clarithromycin, refer to their respective full Prescribing Information

For more information about ACIPHEX®, see full Prescribing Information.

Click here to view full Prescribing Information for ACIPHEX®.

 
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